This study presents the evaluation of cytotoxic activity of our first therapeutic drug candidate based of light zinc isotope 64Zn enriched to >99% against malignant cells. The studied tumor cells, and especially MB16 melanoma and L1210 leukemia cells, were most sensitive to the cytotoxic effects of KLS-1.

This publication presents our small, non-registrational, first-in-human "learning" study of KLS1 (Zinc-64 Aspartate) in patients with oncological and neurodegenerative diseases. The purpose of this study was to establish initial dose of KLS1 for treatment of patients with various pathologies prior to conducting full-scale registrational Phase 1 clinical trial.

Dr. Kesari is ranked among the top 1% of neuro-oncologists and neurologists in the United States and is an internationally recognized scientist and clinician. He believes that in order to cure patients with brain tumors we first need to gain a better molecular and biological understanding of the disease.

Dr. Kesari presents the Pacific Neuroscience Institute's Phase 1 Foundation, which helps the innovative drug developers to test new investigational drug candidates that promise to be safer and more effective, and to help cancer patients to survive cancer for longer.

Isotopic fractionation occurs naturally as we age because of the exposure to dietary and environmental factors, and medication intake. This leads to a disruption of enzymatic, metabolic, and other biological processes important to human health. 

Removing zinc from the extracellular milieu results in decreased activity of deoxythymidine kinase and reduced levels of adenosine(5′)tetraphosphate(5′)-adenosine. Hence, zinc may directly regulate DNA synthesis through these systems..

Animal study of the relations of total zinc, manganese, nucleic acids, and protein in the livers of control, hypophysectomized, and calorie-restricted rats.

Most people fail to exercise. Proteostasis is induced during exercise and zinc plays an essential role in several of the associated pathways.

Investigations on zinc isotope fractionation in breast cancer tissue using in-vitro cell culture uptake-efflux experiments.